Cynthia Grim, ThermoFisher

Traditional PFAS analysis methods can be highly labor intensive, requiring, for example, SPE extraction of 250 to 500 mL of water. Lengthy sample preparation additionally provides opportunities for contamination occur. In this method, we describe an automated dispersive liquid-liquid microextraction method coupled with a high-resolution MS1-only analyzer for the analysis of PFAS in multiple matrices. In order to provide additional analyte confirmation, in-source fragmentation ions as well as two retention times were used. This approach was applied to real groundwater, soil, and food samples.